Burnside Bridge Road, at the bridge over Antietam Creek, was closed Sunday night, according to Washington County Emergency Services.
Earlier Sunday, some roads near Conococheague Creek were closed.
On Sunday morning, Conococheague Creek at Fairview hit 13.63 feet and remained above the 10-foot flood stage Sunday night, according to the National Weather Service.
By 4 a.m. Monday, the creek was at 11.4 feet, the weather service reported. It was expected to recede below flood stage after 2 p.m. Monday.
A flood warning for Opequon Creek near Martinsburg, W.Va., was canceled Monday morning, according to the weather service.
There were no road closures Monday in Berkeley County due to high water.
The Potomac River at Harpers Ferry crested Monday morning at about 18.9 feet, above the flood stage of 18 feet, according to the National Weather Service Advanced Hydrological Prediction Service.
By early afternoon, the river level had fallen to 18.3 feet.