Firefighters removed John Huse Sr., 34, of Charles Town, W.Va., from the wreckage. Huse died as he was being taken to Jefferson Memorial Hospital, Reagan said.
The driver of the car, Darryl Wayne Dodson Jr., 22, also of Millville, was taken by ambulance to Jefferson Memorial Hospital, then flown to Inova Fairfax Hospital in Virginia, where he was being treated for a fractured neck, Reagan said.
Herbert Dodson and Darryl Dodson were brothers and Huse was a friend, Reagan said.
Millville is a small unincorporated community about three miles south of Harpers Ferry, W.Va.
Darryl Dodson was sitting in a driveway by the wreck site when emergency personnel arrived.
While speaking to emergency officials, Darryl Dodson inquired about his girlfriend - the owner of the 2001 Ford Taurus. After finding her purse and a wallet containing her identification inside the car, police and emergency medical personnel searched the area for her but did not find anybody.
A Maryland State Police helicopter called to help look for her also found nothing.
After leaving the wreck site and heading to the hospital, Reagan found the woman there with family members. He said he does not believe she was in the car when it wrecked.
Reagan said the car sideswiped a tree, then went back on the road, coming to rest facing in the wrong direction.
What caused the driver to run off the road is not known, Reagan said. A witness told police the car appeared to be speeding, Reagan said.
Both air bags in the car deployed, and indications are that nobody was wearing a seat belt, Reagan said.
The wreck remains under investigation, Reagan said.
Deputies V. Tionj and S. Holtz assisted, as well as accident reconstructionist Cpl. R.L. Fletcher. Volunteers with Independent Fire Co., Blue Ridge Fire Department and Harpers Ferry Fire Department responded, as well as an ambulance with the county's Ambulance Authority.
Mission Road was closed for 2 1/2 to three hours.