Both of the people in the Hyundai were taken to City Hospital in Martinsburg, W.Va., where they were treated for minor injuries, McCulley said. He declined to release their names.
Lupis' body was sent to the Maryland state medical examiner's office in Baltimore for an autopsy.
Shortly before the wreck, Lupis left his job at World Kitchen in Greencastle, Pa., McCulley said.
A woman driving in front of Lupis told police that she saw Lupis' car in her rearview mirror, and saw him swerve to the left. The side of his car was then hit by the front of the SUV, McCulley said.
Michele Potts, Lupis' sister, said Lupis was the youngest of eight siblings. He was a champion wrestler at Martinsburg High School, she said.
Never married, Lupis had no children. He leaves behind a girlfriend and a large, close family, Potts said.
"He loved being around us a lot," she said.
Over the summer Lupis was diagnosed with Lyme disease and suffered from joint pain and other problems associated with the disease, which is caused by a tick bite, Potts said. He had returned to work in November, with his doctor's permission, she said.
Potts said her brother's doctor had warned that he might have additional problems in the future.
As he headed home from work, Lupis called his girlfriend to tell her he was in a lot of pain, Potts said.
Lupis tended to keep to himself, his sister said. "He was a pretty private kid," she said.
McCulley said he did not believe Lupis was wearing his seat belt and his car did not have air bags. Both people in the SUV were wearing their seat belts and their air bags deployed.
The right-hand lane of Interstate 81 was shut down as police investigated.
Emergency officials with Bedington Volunteer Fire Department and Berkeley County Ambulance Authority responded.