It is the fourth title for Pazarentzos, who claimed three straight wins from 1989 to 1991.
That was before she gave birth to her two children.
Ironically, she came to the event with her children to watch her husband, Mike Spinnler, run. McCullough's offer allowed the Hagerstown resident to run as well.
"That was pretty incredible. That was real generous for her to do that," Pazarentzos said.
And while years have passed, Pazarentzos proved she can still run with the best, even on a difficult course.
"It's a challenging course ... it's not a killer course, but it's challenging ... I kind of enjoyed it."
Maureen Hall finished third in 41:53.0.
While McCullough gets a personal assist for Pazarentzos' win, the champion got plenty of support from the crowd.
"The people were yelling and screaming and giving me so much support, it's just wonderful," she said.
Jaime Dick, who finished third in last year's men's 10K, took the top spot this year, winning by almost 2:30 over Paul Spurrier.
Dick, a Williamsport resident, had a rather specific reason for wanting to win.
"I really needed the 200 bucks ... I just got my car insurance bill, and I figured that would be a good way to pay it off," he said.
Dick, who led at the halfway point by more than a minute, was never challenged.
"I knew I had a good shot at winning," he said. "I was kinda looking around hoping someone fast might show up."
The top man in the master's division pulled a double, as Ron Knepper, 48, also finished third in the men's race in 36:06.7.
It marks the first time in meet history a masters runner has cracked the overall top three.
Ruth Riemenschneider, 41, won the women's masters race in 44:32.4.