The agency is "aggressively developing plans for replacement" of Disque and Baccala, said John C. Howard, Hagerstown-Washington County Economic Development director.
With both jobs open, the commission is considering restructuring the office, Howard said.
He wouldn't elaborate on those plans.
Howard said he doesn't expect the resignations to hurt the agency's efforts.
"We will continue to function as normal," he said.
Howard said he's pleased that both Baccala and Disque have been given opportunities to move forward in their careers.
"I know they'll do well," he said.
After almost eight years with the commission, Baccala said she was ready for something different and that the coordinator job sounded challenging.
An extension of economic development, the job is more in line with her educational background, she said.
Baccala said she concentrated on human resources development in her graduate studies in public administration at Florida State University in Tallahassee.
"My whole goal was to actually work with individuals," she said.
Baccala said she was excited about six agencies pooling their resources with the goal of making sure there's a job for everyone and that everyone is trained and ready for the work force.
The One-Stop Employment Partnership is a partnership of Frederick Community College, the Job Training Agency, Frederick County Public Schools, Frederick County Department of Social Services, the Division of Rehabilitation Services and the Department of Labor, Licensing and Regulation.