The Washington County Human Development Council plans to use the store for on-the-job training for its mentally and physically disabled clients, said Executive Director Ron Harsh.
Senior citizens in the Alexander House, Potomac Towers and Walnut Towers, as well as residents in the immediate area of the store, could call for delivery, Harsh said.
If the Center Street store is successful, satellite stores could be opened downtown and throughout the county, Harsh said.
Harsh said he hopes to open the store in early March. The former Gossard's store closed there about two years ago.
Council clients will fix up the store, which would start off with an inventory of nonperishable items as well as bread, milk and eggs, he said.
Zoning board members William Wantz, Anthony J. Dattilio and Fay Smith also approved several other cases, Davis said. Members Clair Baker and David C. Hanlin were absent.
A request was granted to continue a nonconforming use in a residential neighborhood for a pizza and salad place at 1301 Marshall St., Davis said.
Approval was conditioned on the business being take-out only, Davis said.
The Marshall Street store used to be Bob and Cora's Corner Store.
The board also said a nonconforming use could continue in a residentially zoned neighborhood so an upholstery shop can move from the South End to the North End.
Tom and Jill Nicoletti, owners of Tri-State Upholstery & Interiors, plan to buy the former Ted's Rent-It Center store at 519 and 523 N. Locust St., Tom Nicoletti has said.
The move would allow the business to expand into a design center and quadruple its space, he said.
The store is now at 10306 Sharpsburg Pike.