Sometimes they're a
member of the opposite sex
Have you ever had a best friend who's a member of the opposite sex?
In the recently released movie, "My Best Friend's Wedding," Julia Roberts' character decides to wreck the engagement of the guy with whom she had a brief college romance and has since accepted as her best friend, suddenly believing him to be her true love.
We asked readers who've had man/woman, girl/guy friendships to let us know if those friendships changed when one of the pals found a steady date or got married, or about any other challenges the friendships faced.