Around 12:25 a.m., a car was stopped near the Holiday Inn on U.S. 40 and the first shooting-related arrest was made, Weaver said.
Mandy Louise Nunemaker, 20, of 55 S. Potomac St., was taken into custody at that time, Weaver said.
Based on information from Nunemaker, deputies then went to the Holiday Inn and took three men into custody, Weaver said.
Shacore Little, 20, of 55 S. Potomac St.; Reshen Bathers, 18, of 138 W. North St.; James Smalls, 20, of 126 High St.; and Nunemaker, were each charged with attempted second-degree murder, first- and second-degree assault, attempted armed robbery and use of a handgun in commission of a crime, Weaver said.
All four are expected to appear sometime today before a Washington County District Court commissioner.
The driver of the car, a 26-year-old Frederick woman, was charged with unrelated drug offenses by Frederick City Police. Weaver said she wasn't involved in the shooting.
The victim in the Motel 6 shooting remained in serious condition this morning at Washington County Hospital.
Steven McCormick, 31, of Crisfield, Md., was shot in the upper chest.
This morning's arrests ended the search for several black men and a blonde white woman who reportedly rented the getaway car, a blue Ford Taurus, in Frederick before the shooting.
That vehicle was found abandoned Wednesday afternoon in Maugansville.
An off-duty police officer spotted the car around 12:30 p.m. Wednesday in the parking lot of Maugansville Community Park, said Washington County Sheriff Charles Mades.
Investigators opened the trunk of the car early Thursday and found a pit bull pup in a cage, investigators said.
"The dog has now found a nice quiet home in the country,'' Weaver said this morning.