During the final three minutes of the third quarter, the Panthers used a 10-2 run to increase their advantage to 42-23. Fleming scored 10 points, while Spade added six in the period for Hancock.
"We gave them a battle in the first quarter," Clear Spring coach Karen Strait said. "After that, we didn't play. ... We have been practicing the way that we have been playing - horribly."
Hancock continued to unleash its offense in the fourth quarter. Fleming scored eight points and Spade added six to thwart any hopes of a Clear Spring rally.
"I am very proud of some of my younger players that stepped up this evening," Hancock coach Jennifer Ruppenthal said. "We got off to a slow start, but we recovered in the second quarter by holding them to three points. The main thing is that we had good overall team effort. We were able to penetrate to the inside to get some points much better in the second half than what we did in the first half."
Fleming - who leads the county with 24.8 points per game - had 26 points, 13 rebounds, seven assists and four steals.
"Hancock has a good player in Amanda Fleming," Strait said. "If you have a player like that, it can help you to win by at least 20 points quite a bit."
Spade added 16 points and 11 rebounds, while Joy McKenzie came off of the bench to add 10 points and seven rebounds. Karla Golden hauled in nine rebounds, Jamie Conley had five steals and Jodie Ross blocked three shots for the Panthers.
Holly Aleshire led Clear Spring (2-12) with 13 points and eight rebounds. Buffy Burger had seven rebounds and Stephanie Kauffman added six. Katie Baker dished off six assists.